Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts

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Title

Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts

Subject

Therapeutics

Description

The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed.

Creator

Arpad Szallasi (Ed.) --- Susan M. Huang (Ed.)

Source

https://www.mdpi.com/books/pdfview/book/645

Publisher

MDPI - Multidisciplinary Digital Publishing Institute

Date

2018

Contributor

Baihaqi

Rights

Creative Commons

Format

PDF

Language

English

Type

Textbooks

Files

Citation

Arpad Szallasi (Ed.) --- Susan M. Huang (Ed.), “Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts,” Open Educational Resource (OER) - Unsyiah Library, accessed October 2, 2022, http://uilis.unsyiah.ac.id/oer/items/show/5009.

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