Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Dublin Core

Title

Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Subject

Medicine

Description

Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis

Creator

Murray-Stewart, Tracy

Source

https://www.mdpi.com/books/pdfview/book/1582

Publisher

MDPI - Multidisciplinary Digital Publishing Institute

Date

2019

Contributor

Baihaqi

Rights

Creative Commons

Format

PDF

Language

English

Type

Textbooks

Files

Citation

Murray-Stewart, Tracy, “Polyamine Metabolism in Disease and Polyamine-Targeted Therapies,” Open Educational Resource (OER) - Unsyiah Library, accessed October 2, 2022, http://uilis.unsyiah.ac.id/oer/items/show/4867.

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